RECENT ADVANCES IN PHOSPHATIDYLINOSITOL PHOSPHATE KINASES (PIPKs) AND THEIR INHIBITORS

Authors

• Mengxia Sun, Michigan State UniversityFollow
• Jian Hu, Michigan State UniversityFollow
• Xuefei Huang, Michigan State UniversityFollow

Keywords

Cancer, Enzymes, Inhibitors, Neurodegenerative Diseases, Phosphatidylinositol Phosphate Kinases, Viral Infection

Disciplines

Biochemistry | Organic Chemistry | Physical Sciences and Mathematics

Abstract

Phosphatidylinositol phosphate kinases (PIPKs) are an important class of enzymes in humans, which produce lipid signaling molecules playing central roles in pathogenesis of diseases such as cancer, neurodegenerative diseases, and viral infection. Consequently, they are attracting increasing attention as drug targets for disease treatment. This review summarizes the functions of the PIPK family enzymes and highlights recent efforts on designing novel inhibitors against PIPKs. These advances are extensively discussed to stimulate interest in this field and promote further development of highly potent and selective inhibitors for innovative therapeutic applications.

Author ORCID Identifier

Xuefei Huang www.orcid.org/0000-0002-6468-5526

Recommended Citation

Sun, Mengxia; Hu, Jian; and Huang, Xuefei (2026) "RECENT ADVANCES IN PHOSPHATIDYLINOSITOL PHOSPHATE KINASES (PIPKs) AND THEIR INHIBITORS," BAU Journal - Science and Technology: Vol. 7: Iss. 2, Article 7.
DOI: https://doi.org/10.54729/2959-331X.1182

ISSN

2959-331X