Volume 4, Issue 2 (2022)
Nathalie Khoueiry Zgheib, MD - Professor, Pharmacology and Toxicology, Pharmacogenetics lab American University of Beirut Faculty of Medicine
I am thrilled to be the guest editor for the BAU Journal of Health and Wellbeing. The current issue covers a range of very important topics covering areas such as bone health. Herein, the authors investigate the community pharmacist knowledge, practice, and barriers regarding osteoporosis's prevention and the genetic susceptibility to osteoarthritis. The issue also covers relevant local and behavioral data on COVID-19 with one even tackling pharmacology, my specialty of interest. Furthermore, the authors tackle an important aspect related to our every day’s health; the food safety practices among food carts.
I am more specifically immersed in a specialized area of pharmacology being phamacogenetics (PGx), the study of inter-individual variations in DNA sequence related to drug response. Our research initially started PGx study with single nucleotide polymorphisms (SNPs) detection for targets known to influence drug outcomes by known mechanisms. We then moved to evaluate known SNPs but for new problems being drug toxicity, disease susceptibility or outcome. More recently, we were able to interrogate a much larger number of genetic variants with genotyping arrays, and collaborated to perform next-generation sequencing (NGS) on a larger number of blood samples from very well phenotyped cohorts or repositories. We then expanded into the field of toxico- and pharmacoepigenetics with translational studies spanning cell culture to epidemiological evaluations on peripheral blood and tissues.
Coming back to COVID-19, we have recently evaluated the role of ACE1 genetic polymorphisms and shown that people who have the ACE1 I allele are more prone to contract the virus, but once infected, patients with the ACE1 D allele have a more severe disease course. These results suggest that genotyping for ACE1 I/D can be used for risk stratification and of prognosis of COVID-19 patients
It is hoped that research results emanating from my research group and other investigators such as authors in this journal pave the way for better health and wellbeing to all.
PREVALENCE OF TEMPOROMANDIBULAR DISORDERS AMONG ORTHODONTIC PATIENTS (CROSS-SECTIONAL CLINICAL SURVEY)
Manar Souhail Youssef, Ahmad Tarabaih, and Aly Osman
GENUS MELALEUCA: PHYTOCHEMISTRY, PHARMACOLOGY AND EFFECT AGAINST COVID-19
mayssaloune ALI kanso, Maha Aboul Ela Prof., Abdalla El-Lakany, and mohamad ali hijazi
ASSESSMENT OF THE LEBANESE COMMUNITY PHARMACIST KNOWLEDGE, PRACTICE AND BARRIERS REGARDING THE PREVENTION OF OSTEOPOROSIS
Noura Issa Khram, Maha Aboul Ela, Mohamad Ali Hijazi, and Lama Soubra
THE EFFECT OF FREQUENTLY WEARING FACE MASKS DURING THE COVID- 19 PANDEMIC ON THE DEVELOPMENT OF ACNE IN ADULTS: A CROSSSECTIONAL DESCRIPTIVE STUDY
Rawan Taleb, Rayyan Jad, Rayan Salem, Noor Lababidi, Nourhan Awassa, Hadi Atchan, and Hiba Deek
KNOWLEDGE OF THE EFFECT OF SYNTHETIC PROTEINS ON THE OVERALL HEALTH IN LEBANESE ADULTS: A CROSS-SECTIONAL STUDY
Zeina Al shoufi, Alaa Al Bardan, Ahmad Shishnieh, Rami Asaad, and Hiba Deek
FOOD SAFETY PRACTICES AMONG FOOD CARTS IN -NORTH LEBANON
Hanin Hassan, Nada El Darra, and Alissar Al Khatib
COVID-19 IN LEBANON: DEMOGRAPHICS AND DISTRIBUTION
Mahdi Fadlallah, Fadi Hobeiche, Marie therese Jamal, and Elie Salem-Sokhn
INTERLEUKIN-16 RS4778889 POLYMORPHISM AND ITS INTERACTION WITH INTERLEUKIN-10 RS1800896 POLYMORPHISM INCREASE THE RISK FOR KNEE OSTEOARTHRITIS IN THE LEBANESE POPULATION
Zeina El-Ali, Fouad Ziade, Hassan Zmerly, and Nisrine Bissar
- Nathalie Khoueiry Zgheib, MD
- Professor, Pharmacology and Toxicology, Pharmacogenetics lab American University of Beirut Faculty of Medicine