INTERLEUKIN-16 RS4778889 POLYMORPHISM AND ITS INTERACTION WITH INTERLEUKIN-10 RS1800896 POLYMORPHISM INCREASE THE RISK FOR KNEE OSTEOARTHRITIS IN THE LEBANESE POPULATION

Authors

Zeina El-Ali, PhD student, Department of Biological Sciences, Faculty of Science, Beirut Arab University, Beirut, LebanonFollow
Fouad Ziade, Associate Professor and Director, Faculty of Public Health III, Lebanese University, Tripoli, LebanonFollow
Hassan Zmerly, Professor in Orthopedics and Traumatology, Villa Erbosa Hospital, Gruppo San Donato, Bologna, ItalyFollow
Nisrine Bissar, Associate Professor and Director, Faculty of Health Sciences, Beirut Arab University, Tripoli, LebanonFollow

English Title

INTERLEUKIN-16 RS4778889 POLYMORPHISM AND ITS INTERACTION WITH INTERLEUKIN-10 RS1800896 POLYMORPHISM INCREASE THE RISK FOR KNEE OSTEOARTHRITIS IN THE LEBANESE POPULATION

Keywords

Polymorphism, Gene-gene interaction, Interleukin-16, Interleukin-10, Knee Osteoarthritis

Disciplines

Architecture | Business | Life Sciences | Medicine and Health Sciences

Abstract

To investigate the effect Interleukin-16 (IL-16) and Interleukin-10 (IL-10) polymorphisms, and their interaction, on knee osteoarthritis (KOA) risk in the Lebanese population. Kompetitive Allele Specific PCR (KASP) genotyping assay was performed to determine IL-16 rs4778889, rs11556218, and rs4072111 and IL-10 rs1800896 polymorphisms in 118 patients diagnosed with KOA ( ≥ 2 points on Kellgren-Lawrence (K&L) radiological classification scale) and 70 controls matched for age and gender (K&L score ≤ 1). After adjusting for age, gender, presence of metabolic disorders, smoking and drinking status, our findings suggest that rs4778889 TT genotype increases the risk for KOA compared to the combined CC and TC genotypes (OR=2.131, 95% CI 1.037 – 4.379, p = 0.04) and that the T allele increases KOA risk compared to the C allele (OR=1.8, 95% CI 1.008 – 3.212, p = 0.047). No significant associations with the disease risk were found for the other studied polymorphisms (p > 0.05). Our data suggest that there is an interaction between IL-16 rs4778889 and IL-10 rs1800896 (p = 0.010). IL-16 rs4778889 TT genotype increases the risk for KOA only among individuals carrying IL-10 rs1800896 GG or GA genotypes (OR=4.821, 95% CI 1.847 – 12.583). None of the IL-16 haplotypes was associated with KOA risk in our study population (p > 0.05). Our findings suggest that IL-16 rs4778889 T allele is associated with KOA and that there is an interaction between this polymorphism and IL-10 rs1800896 with regard to KOA.

Author ORCID Identifier

Zeina El-Ali - https://orcid.org/0000-0002-3841-0545

Fouad Ziade - https://orcid.org/0000-0001-6663-3861

Hassan Zmerly - https://orcid.org/0000-0003-3353-1759

Nisrine Bissar - https://orcid.org/0000-0003-4958-6615

Recommended Citation

El-Ali, Zeina; Ziade, Fouad; Zmerly, Hassan; and Bissar, Nisrine (2022) "INTERLEUKIN-16 RS4778889 POLYMORPHISM AND ITS INTERACTION WITH INTERLEUKIN-10 RS1800896 POLYMORPHISM INCREASE THE RISK FOR KNEE OSTEOARTHRITIS IN THE LEBANESE POPULATION," BAU Journal - Health and Wellbeing: Vol. 4: Iss. 2, Article 8.
DOI: https://doi.org/10.54729/UPGP4920