REVIEW ON CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES OF GENUS FERULA

Authors

Rima Mohammad Kheir Boukhary, Assistant Professor, Pharmaceutical Sciences Department, School of Pharmacy, Lebanese International University, Beirut, LebanonFollow
Zeina Omeiche, PharmD, Pharmaceutical Sciences Department, Faculty of Pharmacy, Beirut Arab University, Beirut, LebanonFollow
Mohamad Ali Hijazi, Associate Professor of Pharmacognosy and Medicinal Plants, Pharmaceutical Sciences Department, Faculty of Pharmacy, Beirut Arab University, Beirut, LebanonFollow
Ali Wassef Assi, Pharmacy student, Faculty of Pharmacy, Beirut Arab University, Beirut, LebanonFollow
Tamar Houri, Pharmacy student, Faculty of Pharmacy, Beirut Arab University, Beirut, LebanonFollow
Lynn Al Jawiche, Pharmacy student, Faculty of Pharmacy, Beirut Arab University, Beirut, LebanonFollow
Maria Dirani, Pharmacy student, Faculty of Pharmacy, Beirut Arab University, Beirut, LebanonFollow
Rasha Abdel Nabi, Pharmacy student, Faculty of Pharmacy, Beirut Arab University, Beirut, LebanonFollow
Mohamad Tabbara, Pharmacy student, Faculty of Pharmacy, Beirut Arab University, Beirut, LebanonFollow
Abdalla El-Lakany, Professor of Chemistry of Natural Products, Dean of Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon; Department of Pharmacognosy, Faculty of Pharmacy, University of Alexandria, EgyptFollow
Maha Aboul Ela Prof., Professor of Pharmacognosy, Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon; Department of Pharmacognosy, Faculty of Pharmacy, University of Alexandria, EgyptFollow

English Title

REVIEW ON CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES OF GENUS FERULA

Keywords

Ferula, Active constituents, Anti-oxidant activity, Phenolic constituents

Disciplines

Medicine and Health Sciences

Abstract

Genus Ferula comprises about 220 species of flowering plants belonging to family Apiaceae, distributed in the Mediterranean region and Asia and used in the treatment of different diseases as anti-oxidant, aphrodisiac, carminative, antinociceptive, anti-depressant, antibacterial, anti-fungal, anti-leishmanial, and anti-inflammatory. Moreover, species of this plant are used for dizziness, asthma, bronchitis, and gastrointestinal discomfort. It was reported that all the pharmacological effects of these plants are due to the presence of different phenolic constituents including flavonoids, sesquiterpenes, coumarins and polysulfides. Sesquiterpene coumarins were responsible for the anti-inflammatory and anti-cancer activities by blocking the 5-lipoxygenase enzyme that catalyzes the biosynthesis of leukotrienes (LTs) being a group of lipid mediators of inflammation . This review covers most of the identified chemical constituents of plants from the genus Ferula reported in literature between 2001 and 2023. In addition, the biological activities of the different species of genus Ferula are presented.

Author ORCID Identifier

Rima Mohammad - ORCID: 0000-0002-3636-846X

Zeina Omeiche - ORCID: 0009-0004-8651-3153

Mohamad Ali Hijazi - ORCID: 0000-0002-9829-235X

Ali Wassef Assi - ORCID: 0009-0005-0872-7815

Tamara Houri - ORCID: 0009-0009-5396-013X

Lynn Al Jawiche - ORCID: 0009-0000-2599-859X

Maria Dirani - ORCID: 0009-0002-0173-8130

Rasha Abdel Nabi - ORCID: 0009-0002- 0359-9736

Mohamad Tabbara - ORCID: 0009-0007-1738-1427

Abdalla El-Lakany - ORCID: 0000-0003-2122-2289

Maha Aboul Ela - ORCID: 0000-0002-9411-4900

Recommended Citation

Boukhary, Rima Mohammad Kheir; Omeiche, Zeina; Hijazi, Mohamad Ali; Assi, Ali Wassef; Houri, Tamar; Al Jawiche, Lynn; Dirani, Maria; Abdel Nabi, Rasha; Tabbara, Mohamad; El-Lakany, Abdalla; and Aboul Ela, Maha Prof. (2024) "REVIEW ON CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES OF GENUS FERULA," BAU Journal - Health and Wellbeing: Vol. 6: Iss. 1, Article 4.
DOI: https://doi.org/10.54729/2789-8288.1200