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English Title

PREVALENCE OF ESBL-PRODUCING ENTEROBACTERIACEAE AMONG LEBANESE PATIENTS WITH URINARY TRACT INFECTIONS

Keywords

Urine, Infection, ESBL, pathogen

Disciplines

Life Sciences | Medicine and Health Sciences

Abstract

Being the most common infections worldwide, Urinary Tract Infections (UTIs) represent a major public health problem. Gram negative bacteria are the main pathogens causing UTIs where Extended spectrum β–lactamase (ESBL)-Producing Enterobacteriaceae, mainly the multi-drug resistant species, such as E. coli sequence type 131 and klebsiella.pneumoniae, account for serious health problems and high economic burden. In Lebanon, data about prevalence of antibiotic resistant pathogens during UTIs are still scarce. In this study we examined the prevalence of ESBL-producing pathogens among Lebanese patients mainly located at Bekaa governorate. This retrospective study included 7241 urine tests that were collected from all the out- and in-patients, presented to Rayak Hospital from 1-1-2019 till 31-12-2019. Among the 7241 urine tests performed, 7.54% were positive. Among the positive samples, 59%, 17.5% and 1% were caused by E. coli, Klebsiella and Proteus, respectively. Other infections (22%) were caused by other types of pathogens. Among the E. coli-positive samples, Klebsiella-positive samples and Proteus-positive samples 45%, 26% and 17% were ESBL producing, respectively. The ESBL- producing pathogens corresponded to 31% of the total positive UTIs. The distribution of these infection-causing pathogens according to age, gender and hospitality condition was also determined. This study shows for the first time the frequency and distribution of ESBL-producing pathogens among Lebanese UTI-patients in Bekaa region.

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