Type 2 diabetes mellitus, metformin, organic cation transporter 1, rs622342 gene polymorphisms
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Metformin is one of the most widely prescribed oral ant diabetic drugs, it is generally used for treating type 2 diabetes mellitus patients. The organic caution transporter 1(OCT1), encoded by the SLC22A1 gene is responsible for the uptake of metformin in the hepatocytes. Polymorphisms in SLC22A1 gene contribute to variable responses to metformin leading to inter-individual variations in its clinical efficacy. We evaluated the impact of SLC22A1 rs622342 gene polymorphisms on the efficacy of metformin in Lebanese type 2 diabetes mellitus patients. A total of 63 patients who were on metformin monotherapy were followed up for 6 months. Single nucleotide polymorphisms were determined using Simple Probe® real-time PCR assay. The percentage reduction of fasting plasma glucose after 3 months were 31 % in patients having AA genotype slightly higher than in patients having AC genotype 30.3 % (P=0.676) but much higher than in patients carrying two copies of ‘‘C’’ allele 19.7% (P < 0.001).The percentage reduction of HbA1c after 3 months were 11.16 % in patients having AA genotype higher than in patients having AC genotype 8.58 % (P=0.04) and much higher than in patients carrying two copies of ‘‘C’’ allele 5.65% (P=0.011).Similar results are shown after 6 months. Although preliminary, these data suggest that metformin response in individuals with diabetes mellitus patients may vary according to rs622342 in SLC22A1.
NAJA, KHALED Department of Biological Sciences, Faculty of Science; EL SHAMIEH, SAID Assistant Professor, Department of Medical Laboratory Technology Department, Faculty of Health Sciences; and FAKHOURY, RAJAA Professor, Faculty of Health Sciences,
"EFFECT OF SLC22A1 GENE POLYMORPHISMS ON METFORMINRESPONSE IN LEBANESE TYPE 2 DIABETES MELLITUS PATIENTS,"
BAU Journal - Health and Wellbeing: Vol. 1
, Article 45.
Available at: https://digitalcommons.bau.edu.lb/hwbjournal/vol1/iss3/45