Ferula hermonis; Phytochemical Content; Analysis; Ferutinin; Neuroprotective.


Architecture | Business | Life Sciences | Medicine and Health Sciences


Ferula hermonis (F. hermonis, Fh) is one of the important medicinal-plants cultivated in Lebanon. The aim of this study is to phytochemically-investigate F. hermonis and its most active compound(s) and to explore their neuroprotective potentials utilizing an in vivo model of glycine receptor. HPLC-DAD investigation was done to identify F. hermonis phytochemical constituents. Combined chromatographic, bio-guided fractionation, and in vivo model of glycine receptor were utilized to identify its most active constituent(s). HPLC has shown that F. hermonis has shown 11 major peaks identified as: (1) Jaeskenin (2.47%), (2) Acetoxy-Ferutinin (3.71%), (3) Lapiferin (4.95%), (4) Siol anisate (6.16%), (5) Fertidin (7.38%), (6) Ferutinin (24.60%), (7) p-Coumariloxy jaekeanadiol (7.29%), (8) Akiferin (5.98%), (9) Ferulenol (23.7%), (10) Ferutidin (4.68%), and (11) Jaekeanadiol benzoate (6.03%). Ferutinin (Ft) was identified as the most active constituent in F. hermonis. The novelty in this work that F. hermonis has shown neuroprotective potentials utilizing an ICV, for the first time, in the in-vivo model of glycine receptor. Ft has shown more significant (p˂ 0.05) neuroprotective potentials than F. hermonis. It could be concluded that F. hermonis has significant neuroprotective potentials and that Ft might be responsible for this activity.



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.